Open chromatin profiling key to identifying leukemia cells of origin
Every cancer starts with a single cell, and Jackson Laboratory (JAX) researchers have found a precise and reliable way—whole-genome profiling of open chromatin—to identify the kind of cell that leads...
View ArticleUnraveling the mystery of why cancer cells survive and thrive
Some cancer cells have a trick up their sleeve to avoid cell death: boosting maintenance of telomeres, the protective "end caps" on chromosomes, and a research team led by Jackson Laboratory (JAX)...
View ArticleVitamin B3 prevents glaucoma in laboratory mice
In mice genetically predisposed to glaucoma, vitamin B3 added to drinking water is effective at preventing the disease, a research team led by Jackson Laboratory Professor and Howard Hughes Medical...
View ArticleSingle-cell analysis reveals subtypes of colorectal tumors
Combining single-cell genomics and computational techniques, a research team including Paul Robson, Ph.D., director of single-cell biology at The Jackson Laboratory (JAX), has defined cell-type...
View Article'bench to bedside to bench': Scientists call for closer basic-clinical...
In the era of genome sequencing, it's time to update the old "bench-to-bedside" shorthand for how basic research discoveries inform clinical practice, researchers from The Jackson Laboratory (JAX),...
View ArticleResearchers block B-cell AID, prevent diabetes in NOD mice
Researchers at The Jackson Laboratory, Cyteir Therapeutics and collaborating institutions have found a way to protect beta cells from destruction—achieving a longtime, elusive goal that could lead to...
View ArticleDendritic cells 'divide and conquer' to elude viral infection while promoting...
A research team led by Jackson Laboratory (JAX) Professor Karolina Palucka, M.D., Ph.D., in collaboration with a research team at Institut Curie in France led by Dr. Nicolas Manel, have addressed a...
View ArticleGlioblastoma 'ecosystem' redefined for more effective immunotherapy trials
A research team has revealed the intrinsic gene expression patterns of glioblastoma (GBM) tumors, insights that could drive more effective treatments for GBM, the most common and deadly malignant...
View ArticleLocation, location, location: Immunization delivery site matters
In vaccination, a certain subpopulation of dendritic cells is vital to triggering the body's adaptive immune system, report researchers at The Jackson Laboratory (JAX), Yale University and Astra-Zeneca.
View ArticleProtein Daple coordinates single-cell and organ-wide directionality in the...
Humans inherited the capacity to hear sounds thanks to structures that evolved millions of years ago. Sensory "hair cells" in the inner ear have the amazing ability to convert sound waves into...
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