Mouse study links delayed female sexual maturity to longer lifespan
An intriguing clue to longevity lurks in the sexual maturation timetable of female mammals, Jackson Laboratory researchers and their collaborators report.
View ArticleResearchers provide definitive proof for receptor's role in synapse development
Jackson Laboratory researchers led by Associate Professor Zhong-wei Zhang, Ph.D., have provided direct evidence that a specific neurotransmitter receptor is vital to the process of pruning synapses in...
View ArticleMolecule treats leukemia by preventing cancer cell repair, scientists report
(Medical Xpress)—Researchers at The Jackson Laboratory have identified a molecule that prevents repair of some cancer cells, providing a potential new "genetic chemotherapy" approach to cancer...
View ArticleCocaine, meth response differ between two substrains of 'Black 6' laboratory...
Researchers including Jackson Laboratory Professor Gary Churchill, Ph.D., have found a single nucleotide polymorphism (SNP) difference in cocaine and methamphetamine response between two substrains of...
View ArticlePotential therapeutic target for wound-healing and cancer identified
A Jackson Laboratory research team led by Professor Lenny Shultz, Ph.D., reports that a protein involved in wound healing and tumor growth could be a potential therapeutic target.
View ArticleGuidelines needed for creating germ cells in vitro, scientists state
Research aimed at developing germ cells—the progenitors of eggs and sperm—in vitro should be held to especially rigorous scientific standards, a distinguished team of reproductive biologists declares...
View ArticleResearchers find new mechanism for neurodegeneration
A research team led by Jackson Laboratory Professor and Howard Hughes Investigator Susan Ackerman, Ph.D., have pinpointed a surprising mechanism behind neurodegeneration in mice, one that involves a...
View ArticleTeam discovers lung regeneration mechanism
A research team led by Jackson Laboratory Professors Frank McKeon, Ph.D., and Wa Xian, Ph.D., reports on the role of certain lung stem cells in regenerating lungs damaged by disease.
View ArticleTeam identifies new mechanism for misfolded proteins in heart disease
A Jackson Laboratory research team has found that the misfolded proteins implicated in several cardiac diseases could be the result not of a mutated gene, but of mistranslations during the "editing"...
View ArticleElectroporation delivery of CRISPR/Cas9 system improves efficiency and...
Jackson Laboratory researchers have shown that using an electric current to deliver the CRISPR/Cas9 system, in order to engineer genetic changes in laboratory mice, is highly efficient and...
View ArticleDanitza Nebor's personal mission to find a cure for sickle-cell disease
For Jackson Laboratory postdoctoral associate Danitza Nébor, Ph.D., studying sickle-cell disease isn't just a research project: It's a personal mission.
View ArticleTeam identifies recurrent fusion genes in gastric cancers
Studying the gastric cancers of 15 Southeast Asian patients, researchers at The Jackson Laboratory, the Genome Institute of Singapore and other institutions identified five recurrent fusion genes, one...
View ArticleResearchers discover mutation involved in neurodegeneration
A mutation that increases the level of a special class of sphingolipids—molecules important to cell structure and signaling—can lead to neurodegeneration due to problems with neuronal membranes,...
View ArticleTreatment restores some function in animal models of spinal muscular atrophy
In work involving several new generations of mouse model development, Jackson Laboratory (JAX) researchers have tested a therapeutic intervention for spinal muscular atrophy (SMA) that restores some...
View ArticleProtein factors tie the genome up in a bow for gene expression
Protein factors are responsible for organizing chromosomes inside the nucleus in three dimensions (3D), forming a shape like a gift bow, with proteins aggregating as the central 'knot' holding the...
View ArticleResearchers identify mutations causing butterfly-shaped eye pigment dystrophy
A butterfly-shaped pigment accumulation in the macula of the eye, which can lead to severe vision loss in some patients, is due to mutations in the alpha-catenin 1 gene (CTNNA1), an international...
View ArticleResearch provides insight into the role of the western diet in Alzheimer's...
Recent research has established associations between certain environmental factors, including eating a western diet and being sedentary, with an increased susceptibility to Alzheimer's disease. In...
View ArticleTandem duplicate phenotype detected in triple-negative breast, other cancers
A research team led by Jackson Laboratory (JAX) President and CEO Edison Liu, M.D., have found a molecular fingerprint of some of the most deadly cancers of women: a genomic configuration described as...
View ArticleBlocking apoptotic response could preserve fertility in women receiving...
Female cancer patients of reproductive age could preserve their fertility during radiation and chemotherapy through treatments that target the DNA damage response in oocytes (the cells that develop...
View ArticleDefining the consequences of genetic variation on a proteome-wide scale
Combining two emerging large-scale technologies for the first time—multiplexed mass spectrometry and a mouse population with a high level of natural genetic diversity —researchers at Harvard Medical...
View ArticleOpen chromatin profiling key to identifying leukemia cells of origin
Every cancer starts with a single cell, and Jackson Laboratory (JAX) researchers have found a precise and reliable way—whole-genome profiling of open chromatin—to identify the kind of cell that leads...
View ArticleUnraveling the mystery of why cancer cells survive and thrive
Some cancer cells have a trick up their sleeve to avoid cell death: boosting maintenance of telomeres, the protective "end caps" on chromosomes, and a research team led by Jackson Laboratory (JAX)...
View ArticleVitamin B3 prevents glaucoma in laboratory mice
In mice genetically predisposed to glaucoma, vitamin B3 added to drinking water is effective at preventing the disease, a research team led by Jackson Laboratory Professor and Howard Hughes Medical...
View ArticleSingle-cell analysis reveals subtypes of colorectal tumors
Combining single-cell genomics and computational techniques, a research team including Paul Robson, Ph.D., director of single-cell biology at The Jackson Laboratory (JAX), has defined cell-type...
View Article'bench to bedside to bench': Scientists call for closer basic-clinical...
In the era of genome sequencing, it's time to update the old "bench-to-bedside" shorthand for how basic research discoveries inform clinical practice, researchers from The Jackson Laboratory (JAX),...
View ArticleResearchers block B-cell AID, prevent diabetes in NOD mice
Researchers at The Jackson Laboratory, Cyteir Therapeutics and collaborating institutions have found a way to protect beta cells from destruction—achieving a longtime, elusive goal that could lead to...
View ArticleDendritic cells 'divide and conquer' to elude viral infection while promoting...
A research team led by Jackson Laboratory (JAX) Professor Karolina Palucka, M.D., Ph.D., in collaboration with a research team at Institut Curie in France led by Dr. Nicolas Manel, have addressed a...
View ArticleGlioblastoma 'ecosystem' redefined for more effective immunotherapy trials
A research team has revealed the intrinsic gene expression patterns of glioblastoma (GBM) tumors, insights that could drive more effective treatments for GBM, the most common and deadly malignant...
View ArticleLocation, location, location: Immunization delivery site matters
In vaccination, a certain subpopulation of dendritic cells is vital to triggering the body's adaptive immune system, report researchers at The Jackson Laboratory (JAX), Yale University and Astra-Zeneca.
View ArticleProtein Daple coordinates single-cell and organ-wide directionality in the...
Humans inherited the capacity to hear sounds thanks to structures that evolved millions of years ago. Sensory "hair cells" in the inner ear have the amazing ability to convert sound waves into...
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